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CNT2 inhibitor-1

CAS No. 880155-70-4

CNT2 inhibitor-1( —— )

Catalog No. M26125 CAS No. 880155-70-4

CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CNT2 inhibitor-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2).
  • Description
    CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2).(In Vitro):CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors.
  • In Vitro
    CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    880155-70-4
  • Formula Weight
    448.483
  • Molecular Formula
    C23H24N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 75 mg/mL (167.24 mM)
  • SMILES
    Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc(cc3)-c3ccccc3)nc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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